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Comparison of voluntary ethanol intake by two pairs of rat lines used as genetic models of anxiety BJMBR
Da Silva,G.E.; Ramos,A.; Takahashi,R.N..
The relationship between anxiety-related behaviors and voluntary ethanol intake was examined in two pairs of rat lines by the oral ethanol self-administration procedure. Floripa high (H) and low (L) rats selectively bred for contrasting anxiety responses in the open-field test, and two inbred strains, spontaneously hypertensive rats (SHR) and Lewis rats which are known to differ significantly when submitted to several behavioral tests of anxiety/emotionality, were used (9-10 animals/line/sex). No differences in the choice of ethanol solutions (2%, days 1-4, and 4%, days 5-8, respectively) in a 2-bottle paradigm were detected between Floripa H and L rats (1.94 ± 0.37 vs 1.61 ± 0.37 g/kg for ethanol intake on day 8 by the Floripa H and L rat lines,...
Tipo: Info:eu-repo/semantics/article Palavras-chave: Anxiety; Ethanol intake; Spontaneously hypertensive rats; Lewis; Selected lines; Inbred strains.
Ano: 2004 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2004001000010
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Efeitos da semicarbazida no esqueleto de ratos Wistar em crescimento Arq. Bras. Med. Vet. Zootec.
Ramos,A.; Pereira,A.; Cabrita,A.S.; Capela e Silva,F..
The effects of semicarbazide hydrochloride on skeletal tissues were evaluated using Wistar rats. In the animals submitted to the administration of semicarbazide, radiological examination showed bone and articular alterations with growth plates enlargement. Histological exams showed irregular patterns and proliferation of chondrocytes and excessive accumulation of extracellular matrix. Immunohistochemical exams showed PCNA positive reaction in pre- and hypertrofic chondrocytes. These results confirm that semicarbazide induces important changes in skeletal tissues and that has potential utility in experimental osteolathryrism
Tipo: Info:eu-repo/semantics/article Palavras-chave: Rato; Wistar; Semicarbazida; Osteolatirismo.
Ano: 2012 URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-09352012000200035
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